| First Author | Gao Z | Year | 2018 |
| Journal | Development | Volume | 145 |
| Issue | 1 | PubMed ID | 29158445 |
| Mgi Jnum | J:270953 | Mgi Id | MGI:6278778 |
| Doi | 10.1242/dev.155861 | Citation | Gao Z, et al. (2018) PDGFRalpha/PDGFRbeta signaling balance modulates progenitor cell differentiation into white and beige adipocytes. Development 145(1):dev155861 |
| abstractText | The relative abundance of thermogenic beige adipocytes and lipid-storing white adipocytes in adipose tissue underlie its metabolic activity. The roles of adipocyte progenitor cells, which express PDGFRalpha or PDGFRbeta, in adipose tissue function have remained unclear. Here, by defining the developmental timing of PDGFRalpha and PDGFRbeta expression in mouse subcutaneous and visceral adipose depots, we uncover depot specificity of pre-adipocyte delineation. We demonstrate that PDGFRalpha expression precedes PDGFRbeta expression in all subcutaneous but in only a fraction of visceral adipose stromal cells. We show that high-fat diet feeding or thermoneutrality in early postnatal development can induce PDGFRbeta(+) lineage recruitment to generate white adipocytes. In contrast, the contribution of PDGFRbeta(+) lineage to beige adipocytes is minimal. We provide evidence that human adipose tissue also contains distinct progenitor populations differentiating into beige or white adipocytes, depending on PDGFRbeta expression. Based on PDGFRalpha or PDGFRbeta deletion and ectopic expression experiments, we conclude that the PDGFRalpha/PDGFRbeta signaling balance determines progenitor commitment to beige (PDGFRalpha) or white (PDGFRbeta) adipogenesis. Our study suggests that adipocyte lineage specification and metabolism can be modulated through PDGFR signaling. |
