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Publication : The structure of the human NDUFV1 gene encoding the 51-kDa subunit of mitochondrial complex I.

First Author  de Coo RF Year  1999
Journal  Mamm Genome Volume  10
Issue  1 Pages  49-53
PubMed ID  9892733 Mgi Jnum  J:52849
Mgi Id  MGI:1330509 Doi  10.1007/s003359900941
Citation  de Coo RFM, et al. (1999) The structure of the human NDUFV1 gene encoding the 51-kDa subunit of mitochondrial complex I. Mamm Genome 10(1):49-53
abstractText  The genomic organization of the human 51-kDa subunit gene (NDUFV1) on human Chromosome (Chr) 11q13 was determined. The NDUFV1 gene consists of 10 exons. Exon 1 encodes for the 20-amino-acids-long import sequence, and exon 1 through 10 codes for the 444-amino-acids-long mature protein. The protein sequence is highly conserved between human and bovine. Northern blotting analysis showed that the NDUFV1 gene expression varies widely among tissues and that in testis a unique mRNA species is present. In comparison with the other complex I flavoproteins, the expression of the 51-kDa gene in pancreatic tissue is high.
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