Primary Identifier | MGI:109473 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 17847 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and protein K48-linked deubiquitination. Predicted to act upstream of or within Wnt signaling pathway and proteolysis. Predicted to be active in cytosol and nucleus. Orthologous to human USP34 (ubiquitin specific peptidase 34). PHENOTYPE: Mice homozygous for a conditional allele activated in early limb bud exhibit reduced osteogenic differentiation and bone formation. [provided by MGI curators] |