| First Author | Berger-Sweeney J | Year | 2006 |
| Journal | Learn Mem | Volume | 13 |
| Issue | 1 | Pages | 4-7 |
| PubMed ID | 16452649 | Mgi Jnum | J:135794 |
| Mgi Id | MGI:3794477 | Doi | 10.1101/lm.73706 |
| Citation | Berger-Sweeney J, et al. (2006) Reduced extinction of hippocampal-dependent memories in CPEB knockout mice. Learn Mem 13(1):4-7 |
| abstractText | CPEB is a sequence-specific RNA binding protein that regulates translation at synapses. In neurons of CPEB knockout mice, synaptic efficacy is reduced. Here, we have performed a battery of behavioral tests and find that relative to wild-type animals, CPEB knockout mice, although similar on many baseline behaviors, have reduced extinction of memories on two hippocampal-dependent tasks. A corresponding microarray analysis reveals that about 0.14% of hippocampal genes have an altered expression in the CPEB knockout mouse. These data suggest that CPEB-dependent local protein synthesis may be an important cellular mechanism underlying extinction of hippocampal-dependent memories. |
