Primary Identifier | MGI:2685830 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 381318 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to be involved in mitotic sister chromatid segregation. Predicted to act upstream of or within cell division and chromosome segregation. Predicted to be located in kinetochore and nuclear speck. Predicted to be part of MIS12/MIND type complex. Orthologous to human NSL1 (NSL1 component of MIS12 kinetochore complex). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming blastocysts. [provided by MGI curators] |