| Primary Identifier | MGI:1202065 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 12649 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables histone H3T11 kinase activity. Involved in negative regulation of gene expression, epigenetic. Acts upstream of or within several processes, including DNA damage checkpoint signaling; G2/M transition of mitotic cell cycle; and inner cell mass cell proliferation. Located in nucleus and replication fork. Part of chromatin. Is expressed in several structures, including adrenal medulla; brain; early conceptus; gonad; and gut. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1). PHENOTYPE: Mice homozygous for disruptions in this gene display ealy embryonic lethality, impaired cell cycle checkpoint function, increase in blastocyst apoptosis, and lack of inner cell mass proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
