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Protein Coding Gene : Trp53 transformation related protein 53

Primary Identifier  MGI:98834 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  22059
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to radiation; intrinsic apoptotic signaling pathway; and positive regulation of programmed cell death. Acts upstream of or within several processes, including mitochondrion organization; negative regulation of cell population proliferation; and regulation of apoptotic process. Located in several cellular components, including chromosome; germ cell nucleus; and mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study several diseases, including breast cancer (multiple); lung cancer (multiple); non-Hodgkin lymphoma (multiple); pancreatic carcinoma (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).
PHENOTYPE: Mutations in this locus affect cell-cycle regulation and apoptosis. Null homozygotes show high, early-onset tumor incidence; some have persistent hyaloid vasculature and cataracts. Truncated or temperature-sensitive alleles cause early aging phenotypes. [provided by MGI curators]
  • synonyms:
  • MGI:3584378,
  • MGI:3584375,
  • MGD-MRK-15247,
  • transformation related protein 53,
  • Trp53,
  • p44,
  • p53,
  • MGI:3584379

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

5 Involved In Mutations

0 Strain

0 Transcripts

15 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

51 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For