| First Author | Martin EL | Year | 2007 |
| Journal | Exp Lung Res | Volume | 33 |
| Issue | 2 | Pages | 99-113 |
| PubMed ID | 17454105 | Mgi Jnum | J:147695 |
| Mgi Id | MGI:3841913 | Doi | 10.1080/01902140701198625 |
| Citation | Martin EL, et al. (2007) Lung mechanics in the TIMP3 null mouse and its response to mechanical ventilation. Exp Lung Res 33(2):99-113 |
| abstractText | Tissue inhibitor of metalloproteinase-3 (TIMP3) null mice develop emphysema-like airspace enlargement due to an enzymatic imbalance. This study investigates how these abnormalities alter lung mechanics and the response to 2 different mechanical ventilation strategies. Phenotypically, TIMP3 null mice had increased compliance, and decreased resistance, tissue damping, and tissue elastance over wild-type controls. Decreased compliance and increased resistance were observed following the injurious ventilation strategy; however, the TIMP3 null response to both ventilation strategies was similar to wild-type mice. In conclusion, TIMP3 null mice have significant alterations in lung mechanics; however, this does not affect their response to ventilation. |
