| Primary Identifier | IPR037426 | Type | Domain |
| Short Name | SNX9_PX |
| description | Sorting nexin 9 (SNX9) has been suggested to be involved in the endocytic process as an accessory factor []. SNX9 has binding sites for both clathrin and adaptor protein AP-2 in a low complexity region, and binds dynamin-2 (Dyn2) by its SH3 domain. SNX9 has its own membrane-binding activity, mediated by a carboxyl-terminal region containing the PX domain and the BAR domain []. Endogenous SNX9 partially co-localizes with AP-2 and Dyn2 at the plasma membrane, and over expression in K562 and HeLa cells of truncated versions of SNX9 inhibits the uptake of transferrin []. Moreover, SNX9 is required for efficient clathrin-mediated endocytosis, which suggests that it functions to regulate dynamin activity [].SNXs are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNX9 also contains a BAR and a SH3 domain. This entry represents the PX domain of sorting nexin-9. The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions []. |
