| First Author | Hou Y | Year | 2021 |
| Journal | Biochem Biophys Res Commun | Volume | 550 |
| Pages | 22-29 | PubMed ID | 33677132 |
| Mgi Jnum | J:305598 | Mgi Id | MGI:6706055 |
| Doi | 10.1016/j.bbrc.2021.02.086 | Citation | Hou Y, et al. (2021) LF-rTMS ameliorates social dysfunction of FMR1(-/-) mice via modulating Akt/GSK-3beta signaling. Biochem Biophys Res Commun 550:22-29 |
| abstractText | Autism spectrum disorders (ASD) are a group of neurological disorders which affect approximately 1% of children around the world. Social dysfunction is one of the two core syndromes of ASD, and still lacks effective treatment. Transcranial magnetic stimulation (TMS) is a noninvasive and safe procedure that uses magnetic fields to modulate neural activity. Whether it were effective in modulating social function remains unclear. By using 3-chamber test, ultrasonic vocalization recording and Western-blotting, we demonstrated that FMR1 (fragile X mental retardation protein) mutant mice, a model of ASD, exhibited obvious defects in social preference and ultrasonic communication. In addition, we detected increase of p-Akt (S473) and p-GSK-3beta (S9), and decrease of p-PSD-95 (T19) in the anterior cingulate cortex (ACC) of FMR1(-/-) mice. Treating FMR1(-/-) mice with 1 Hz repetitive TMS (rTMS) exerted a long lasting effect in improving both the ultrasonic communication and social preference, as well as restoring the levels of Akt/GSK-3beta activity and spine density in the FMR1(-/-)ACC. Our data, for the first time, demonstrated a beneficial effect of low frequency rTMS (LF-rTMS) on the social function of FMR1(-/-) mice and an involvement of Akt/GSK-3beta signaling in this process, indicating LF-rTMS as a potential therapeutic strategy for ASD patients. |
