| Primary Identifier | MGI:6392387 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Insyn1 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The molecular lesion is an 11-bp missense deletion in exon 2 causing an out-of-frame mutation following 34 amino-acids and a premature stop codon in a highly conserved region of the gene. Homology-Independent Targeted Integration (HITI) labeling revealed loss of puncta staining in hippocampal neurons from homozygous mutant mice, thus confirming absence of protein expression. |
