| First Author | Zerenturk EJ | Year | 2017 |
| Journal | Methods Mol Biol | Volume | 1583 |
| Pages | 65-72 | PubMed ID | 28205167 |
| Mgi Jnum | J:324514 | Mgi Id | MGI:6884211 |
| Doi | 10.1007/978-1-4939-6875-6_6 | Citation | Zerenturk EJ, et al. (2017) The Use of L-sIDOL Transgenic Mice as a Murine Model to Study Hypercholesterolemia and Atherosclerosis. Methods Mol Biol 1583:65-72 |
| abstractText | There are many advantages to the use of mice as a model to study the regulation of cholesterol metabolism. Common models of hypercholesterolemia include low-density lipoprotein receptor deficient (LDLR -/-) mice and apolipoprotein E deficient (ApoE) -/- mice. Herein, we describe the recently generated mouse model, L-sIDOL Tg mice, which express a dominant active form of Inducible Degrader Of the Low-density lipoprotein receptor (IDOL) in a liver-specific manner. This murine model offers significant advantages over previously established models for the study of hypercholesterolemia and atherosclerosis. |
