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Publication : An age-dependent novel hyperinnervation of circumvallate papillae by tyrosine hydroxylase-containing nerve fibers in NGF-overexpressing transgenic mice.

First Author  Takami S Year  1996
Journal  Brain Res Volume  707
Issue  2 Pages  303-7
PubMed ID  8919310 Mgi Jnum  J:31485
Mgi Id  MGI:78993 Doi  10.1016/0006-8993(95)01336-9
Citation  Takami S, et al. (1996) An age-dependent novel hyperinnervation of circumvallate papillae by tyrosine hydroxylase-containing nerve fibers in NGF-overexpressing transgenic mice. Brain Res 707(2):303-7
abstractText  The density of protein gene product 9.5- and tyrosine hydroxylase-immunoreactive nerve fibers innervating circumvallate papillae of the tongue was substantially increased in transgenic mice that overexpressed nerve growth factor (NGF) when compared with age-matched controls. The fiber density was age-dependent. Only transgenic mice contained NGF-immunoreactive basal cells in the vicinity of taste buds, indicating that target-derived NGF induced novel hyperinnervation of the circumvallate papillae.
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