| First Author | Herzog H | Year | 1993 |
| Journal | J Biol Chem | Volume | 268 |
| Issue | 9 | Pages | 6703-7 |
| PubMed ID | 8095935 | Mgi Jnum | J:4232 |
| Mgi Id | MGI:52728 | Doi | 10.1016/s0021-9258(18)53306-8 |
| Citation | Herzog H, et al. (1993) Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor. J Biol Chem 268(9):6703-7 |
| abstractText | A 14-kilobase pair (kb) region of genomic DNA encoding the human neuropeptide Y Y1-receptor gene including 3'- and 5'-flanking sequences has been cloned and the human gene localized to chromosome 4q(31.3-32). In contrast to the contiguous structure of most G protein-coupled receptor genes, the NPY Y1 receptor gene is divided into three exons. A small 5'-exon of the mRNA untranslated region is separated by a 6-kb intron from the second exon. The coding region of the receptor is interrupted by a small intron, containing an in-frame stop codon, shortly after the proposed fifth transmembrane domain. In the 5'-flanking region a potential cAMP-response element and an AP-2 site, in addition to a TATA-like sequence and a typical CAAT, box are present. A single point mutation within the 6-kb intron generates a PstI polymorphic site with a highly informative allele frequency of 54:46% in the population. |
