| First Author | Chen D | Year | 1999 |
| Journal | Science | Volume | 284 |
| Issue | 5423 | Pages | 2174-7 |
| PubMed ID | 10381882 | Mgi Jnum | J:64957 |
| Mgi Id | MGI:1891510 | Doi | 10.1126/science.284.5423.2174 |
| Citation | Chen D, et al. (1999) Regulation of transcription by a protein methyltransferase. Science 284(5423):2174-7 |
| abstractText | The p160 family of coactivators, SRC-1, GRIP1/TIF2, and p/CIP, mediate transcriptional activation by nuclear hormone receptors. Coactivator-associated arginine methyltransferase 1 (CARM1), a previously unidentified protein that binds to the carboxyl-terminal region of p160 coactivators, enhanced transcriptional activation by nuclear receptors, but only when GRIP1 or SRC-1a was coexpressed. Thus, CARM1 functions as a secondary coactivator through its association with p160 coactivators. CARM1 can methylate histone H3 in vitro, and a mutation in the putative S-adenosylmethionine binding domain of CARM1 substantially reduced both methyltransferase and coactivator activities. Thus, coactivator-mediated methylation of proteins in the transcription machinery may contribute to transcriptional regulation. |
