| Primary Identifier | IPR032917 | Type | Family |
| Short Name | TRIM5 |
| description | Tripartite motif-containing protein 5 (TRIM5) is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus invasion of the target cell cytoplasm []. It is a regulator of autophagy [].Interestingly, while each primate species has a single TRIM5 gene, mice have at least seven TRIM5 homologues that cluster into two groups, Trim12a, -b, and -c and Trim30a, -b, -c, and -d. The three Trim12 proteins activated innate immune signaling, while the Trim30 proteins did not []. |
