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Protein Coding Gene : Sema4c sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Primary Identifier  MGI:109252 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  20353
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in muscle cell differentiation; nervous system development; and semaphorin-plexin signaling pathway. Located in postsynaptic density and synaptic vesicle membrane. Is expressed in several structures, including brain; enamel organ; ganglia; genitourinary system; and sensory organ. Orthologous to human SEMA4C (semaphorin 4C).
PHENOTYPE: Mice homozygous for a targeted mutation exhibit exencephaly, neonatal lethality, and abnormal cerebellum morphology. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-38297,
  • AI426163,
  • semaphorin C-like 1,
  • Semaf,
  • Sema4c,
  • MGI:2138227,
  • M-Sema F,
  • Semai,
  • Semacl1,
  • semaphorin I,
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C,
  • expressed sequence AI426163
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