| First Author | Ko JA | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 10 | Pages | 2236-42 |
| PubMed ID | 15811348 | Mgi Jnum | J:97419 |
| Mgi Id | MGI:3575391 | Doi | 10.1016/j.febslet.2005.03.022 |
| Citation | Ko JA, et al. (2005) Requirement of the transmembrane semaphorin Sema4C for myogenic differentiation. FEBS Lett 579(10):2236-42 |
| abstractText | Semaphorins constitute a large family of signaling proteins that contribute to axonal guidance. Here we demonstrate that the transmembrane semaphorin Sema4C is up-regulated both in the early stage of differentiation of C2C12 mouse skeletal myoblasts into myotubes and during injury-induced muscle regeneration in vivo. Depletion of Sema4C in C2C12 cells resulted in marked attenuation of myotube formation. A fusion protein containing the extracellular Sema domain and a peptide corresponding to the intracellular COOH-terminal region of Sema4C each inhibited the differentiation of C2C12 cells. These findings indicate that Sema4C-mediated interaction among myoblasts plays an important role in terminal myogenic differentiation. |
