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Allele : Lrba<em2Btlr> LPS-responsive beige-like anchor; endonuclease-mediated mutation 2, Bruce Beutler

Primary Identifier  MGI:6303985 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Lrba
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  The CRISPR/Cas9 system and sgRNA 5'-AATGCGAAACATGGTGGATC-3' was used to generate the mice. The CRISPR/Cas9 system generated a 1-base pair deletion at c.4177del (NM_030695.2). The mutation is predicted to cause a frame-shifted protein product beginning after amino acid 1297 of the protein and termination after the inclusion of 25 aberrant amino acids.
  • mutations:
  • Intragenic deletion
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

3 Publication categories

Trail: Allele