Primary Identifier | MGI:6303985 | Allele Type | Endonuclease-mediated |
Attribute String | Null/knockout | Gene | Lrba |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The CRISPR/Cas9 system and sgRNA 5'-AATGCGAAACATGGTGGATC-3' was used to generate the mice. The CRISPR/Cas9 system generated a 1-base pair deletion at c.4177del (NM_030695.2). The mutation is predicted to cause a frame-shifted protein product beginning after amino acid 1297 of the protein and termination after the inclusion of 25 aberrant amino acids. |