Primary Identifier | MGI:2443063 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 213435 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables calmodulin-dependent protein kinase activity and myosin light chain kinase activity. Involved in sarcomere organization. Located in cytoplasm. Colocalizes with actin cytoskeleton. Is expressed in heart atrium; heart ventricle; inner ear; and liver. Orthologous to human MYLK3 (myosin light chain kinase 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit cardiac hypertrophy, reduced cardiac function and increased response of heart to induced stress. [provided by MGI curators] |