Primary Identifier | MGI:3818933 | Allele Type | Targeted |
Attribute String | Null/knockout, Reporter | Gene | Aire |
Transmission | Germline | Strain of Origin | (C57BL/6NCrlj x CBA/JNCrlj)F1 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Genomic sequence from immediately after the Kozak sequence in exon 1 to the exon 2 was replaced with GFP and a floxed neo cassette via homologous recombination. The neo cassette was removed via in vivo Cre mediated recombination. Immunohistochemical analysis in heterozygous mice indicates that the pattern of GFP expression is similar to the pattern of endogenous gene expression. |