| Primary Identifier | MGI:1921430 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 74180 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Acts upstream of or within defense response to bacterium and regulation of macrophage activation. Located in extracellular space. Is expressed in auditory bulla; epithelium; and respiratory system. Human ortholog(s) of this gene implicated in bronchiolitis; idiopathic pulmonary fibrosis; and urinary bladder cancer. Orthologous to human MUC5B (mucin 5B, oligomeric mucus/gel-forming). PHENOTYPE: Mice homozygous for a knock-out allele accumulate materials in the upper and lower airways leading to chronic infection and inflammation that does not resolve and results in premature death. Macrophage function is impaired. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
