| Primary Identifier | MGI:5707932 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Tle4 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A loxP site was inserted upstream of exon 2. A floxed neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2, which encodes a lysine zipper motif, and results in a truncated protein. Western blot analysis confirmed the absence of protein expression in brain and lung. |
