| First Author | Lin SX | Year | 2001 |
| Journal | Nat Cell Biol | Volume | 3 |
| Issue | 6 | Pages | 567-72 |
| PubMed ID | 11389441 | Mgi Jnum | J:69943 |
| Mgi Id | MGI:2135811 | Doi | 10.1038/35078543 |
| Citation | Lin SX, et al. (2001) Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells. Nat Cell Biol 3(6):567-72 |
| abstractText | RME-1 is an Eps15-homology (EH)-domain protein that was identified in a genetic screen for endocytosis genes in Caenorhabditis elegans. When expressed in a CHO cell line, the worm RME-1 protein and a mouse homologue are both associated with the endocytic recycling compartment. Here we show that expression of a dominant-negative construct with a point mutation near the EH domain results in redistribution of the endocytic recycling compartment and slowing down of transferrin receptor recycling. The delivery of a TGN38 chimaeric protein to the trans-Golgi network is also slowed down. The function of Rme-1 in endocytic recycling is evolutionarily conserved in metazoans as shown by the protein's properties in C. elegans. |
