Primary Identifier | MGI:2451291 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Atp1a2 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The insertion of an hprt cassette into exon 4 resulted in an alpha 2 isoform specific disruption. Both alpha 2 transcript and protein levels were reduced by ~50% in heterozygous mutant hearts. An aberrant alpha 2 transcript was detected but was not expected to produce a functional protein. |