| First Author | Mombereau C | Year | 2004 |
| Journal | Eur J Pharmacol | Volume | 497 |
| Issue | 1 | Pages | 119-20 |
| PubMed ID | 15321743 | Mgi Jnum | J:101866 |
| Mgi Id | MGI:3605592 | Doi | 10.1016/j.ejphar.2004.06.036 |
| Citation | Mombereau C, et al. (2004) Altered response to benzodiazepine anxiolytics in mice lacking GABA B(1) receptors. Eur J Pharmacol 497(1):119-20 |
| abstractText | Recently, we demonstrated that mice lacking the GABA(B(1)) subunit were more anxious than wild-type animals in several behavioural paradigms, most notably in the light-dark test. In an attempt to assess the effects of classical benzodiazepine anxiolytics on anxiety-like behaviour observed in these mice, animals were administered either chlordiazepoxide (10 mg/kg, p.o.) or diazepam (7.5 mg/kg, p.o.) prior to testing in the light-dark box. Surprisingly, in contrast with the wild-type mice, neither benzodiazepines decreased anxiety-like behaviour in GABA(B(1))(-/-) mice. These data suggest that targeted deletion of GABA(B(1)) subunit alters GABA(A) receptor function in vivo. |
