| First Author | Fendt M | Year | 2011 |
| Journal | Behav Brain Res | Volume | 217 |
| Issue | 1 | Pages | 1-9 |
| PubMed ID | 20888368 | Mgi Jnum | J:294690 |
| Mgi Id | MGI:6457136 | Doi | 10.1016/j.bbr.2010.09.022 |
| Citation | Fendt M, et al. (2011) Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response. Behav Brain Res 217(1):1-9 |
| abstractText | The present study investigated the phenotype of heterozygous and homozygous neuropeptide S receptor (Npsr) deficient C57BL/6 mice in NPS- and cocaine induced hyperactivity, spontaneous and reactive locomotor activity, elevated plus maze, conditioned fear, and prepulse inhibition of the acoustic startle response. In Npsr-deficient mice, a strong reduction of spontaneous locomotor activity and of the startle magnitude was observed; heterozygous mice had an intermediate phenotype. In the other experiments, Npsr deficiency leads to no or only a very modest phenotype. These results support an important role of neuropeptide S in regulating locomotor activity. |
