Primary Identifier | MGI:7548564 | Allele Type | Endonuclease-mediated |
Gene | Ripk1 | Strain of Origin | (C57BL/6 x DBA/2)F1 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Lysine codon 612 (AAA) in exon 11 was changed to arginine (CGC) (p.K612R) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation interferes with ubiquitination and inhibits activation of the encoded peptide. |