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Allele : Ripk1<em1Yuan> receptor (TNFRSF)-interacting serine-threonine kinase 1; endonuclease-mediated mutation 1, Junying Yuan

Primary Identifier  MGI:7548564 Allele Type  Endonuclease-mediated
Gene  Ripk1 Strain of Origin  (C57BL/6 x DBA/2)F1
Is Recombinase  false Is Wild Type  false
molecularNote  Lysine codon 612 (AAA) in exon 11 was changed to arginine (CGC) (p.K612R) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation interferes with ubiquitination and inhibits activation of the encoded peptide.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Ripk1<K612R>,
  • Ripk1<K612R>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories

Trail: Allele