| First Author | Weizman OE | Year | 2019 |
| Journal | Nat Immunol | Volume | 20 |
| Issue | 8 | Pages | 1004-1011 |
| PubMed ID | 31263280 | Mgi Jnum | J:305563 |
| Mgi Id | MGI:6706462 | Doi | 10.1038/s41590-019-0430-1 |
| Citation | Weizman OE, et al. (2019) Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nat Immunol 20(8):1004-1011 |
| abstractText | Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of tissue-resident ILCs has remained unclear. In the present study, it was found that liver-resident type 1 ILCs (ILC1s) expanded locally and persisted after the resolution of infection with mouse cytomegalovirus (MCMV). ILC1s acquired stable transcriptional, epigenetic and phenotypic changes a month after the resolution of MCMV infection, and showed an enhanced protective effector response to secondary challenge with MCMV consistent with a memory lymphocyte response. Memory ILC1 responses were dependent on the MCMV-encoded glycoprotein m12, and were independent of bystander activation by proinflammatory cytokines after heterologous infection. Thus, liver ILC1s acquire adaptive features in an MCMV-specific manner. |
