| First Author | Cunnick J | Year | 1992 |
| Journal | Biochem Biophys Res Commun | Volume | 184 |
| Issue | 1 | Pages | 461-6 |
| PubMed ID | 1314595 | Mgi Jnum | J:476 |
| Mgi Id | MGI:49013 | Doi | 10.1016/0006-291x(92)91216-d |
| Citation | Cunnick J, et al. (1992) Carriers of the mouse rd gene have reduced levels of the beta subunit of the retinal cyclic GMP phosphodiesterase. Biochem Biophys Res Commun 184(1):461-6 |
| abstractText | Polyclonal antipeptide antisera have been utilized to quantitate the amount of retinal rod outer segment cGMP phosphodiesterase alpha and beta catalytic subunits present in retinas from C57BL/6J mice which are normal or carriers for the rd gene defect. Results suggest that the quantity of PDE-beta subunit is reduced in carrier mice while PDE-alpha and PDE-gamma are not affected. In 21-day-old mice, the PDE-beta was reduced by about one-half while adult carrier mice had even more reduced levels of PDE-beta. Since PDE alpha was not reduced, this suggests that synthesis of PDE alpha and PDE beta may not be coordinately controlled. |
