First Author | Baron A | Year | 1987 |
Journal | EMBO J | Volume | 6 |
Issue | 10 | Pages | 2977-86 |
PubMed ID | 2891503 | Mgi Jnum | J:33943 |
Mgi Id | MGI:81423 | Doi | 10.1002/j.1460-2075.1987.tb02603.x |
Citation | Baron A, et al. (1987) Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex. EMBO J 6(10):2977-86 |
abstractText | Hox-1.6, a mouse homeo-box-containing gene member of the Hox-1 complex, is described. The Hox-1.6 homeo-box shows more divergence than the other members of the complex with the Drosophila Antennapedia-like homeo-box class. This previously undescribed gene was studied with respect to its transcription pattern and was found to be expressed during mouse fetal development in an intestine-specific manner in adults, and in tumours or cell types exhibiting early endodermal-like differentiation. The study of embryonic partial Hox-1.6 cDNA clones revealed structural features common to other Drosophila and vertebrate homeo-box-containing genes, but also indicated that Hox-1.6 transcripts might display splicing patterns more complex than those known for other vertebrate homeo-genes. One of these cDNA clones contains a rather short open reading frame which would encode a protein of approximately 14.5 kd. The use of this clone as a probe for S1 nuclease mapping confirmed that different Hox-1.6 transcripts were present both in embryonic total RNA and in embryonal carcinoma cell cytoplasmic RNA. These various transcripts are probably generated by an alternative splicing mechanism and may thus encode a set of related proteins. |