| First Author | Ito C | Year | 2007 |
| Journal | Eur J Med Chem | Volume | 42 |
| Issue | 7 | Pages | 902-9 |
| PubMed ID | 17316910 | Mgi Jnum | J:122712 |
| Mgi Id | MGI:3715092 | Doi | 10.1016/j.ejmech.2006.12.024 |
| Citation | Ito C, et al. (2007) Synthetic cinnamylphenol derivatives as cancer chemopreventive agents. Eur J Med Chem 42(7):902-9 |
| abstractText | Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters). |
