First Author | Zimniak P | Year | 1992 |
Journal | FEBS Lett | Volume | 313 |
Issue | 2 | Pages | 173-6 |
PubMed ID | 1426286 | Mgi Jnum | J:3306 |
Mgi Id | MGI:51819 | Doi | 10.1016/0014-5793(92)81438-r |
Citation | Zimniak P, et al. (1992) A subgroup of class alpha glutathione S-transferases. Cloning of cDNA for mouse lung glutathione S-transferase GST 5.7. FEBS Lett 313(2):173-6 |
abstractText | A full-length cDNA clone encoding the previously purified mouse glutathione S-transferase GST 5.7 [(1991), Biochem. J. 278, 793-799] has been isolated from a mouse lung cDNA library in lambda gt11. Sequencing of the clone revealed the presence of microheterogeneity in GST 5.7. Comparison of the deduced protein sequence with other glutathione S-transferases, together with previous information available on GST 5.7, indicates that the enzyme belongs to a novel subgroup within the alpha class of glutathione S-transferases. Members of the subgroup, which also include the rat GST 8-8 and perhaps chicken GST CL3, show high sequence homology with each other, but only moderate similarity to other alpha class enzymes. They share a substrate specificity profile that resembles pi-class enzymes, and are active in the conjugation of lipid peroxidation products. |