|  Help  |  About  |  Contact Us

Protein Coding Gene : Ros1 Ros1 proto-oncogene

Primary Identifier  MGI:97999 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  19886
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables protein phosphatase binding activity. Involved in columnar/cuboidal epithelial cell development; regulation of ERK1 and ERK2 cascade; and spermatogenesis. Acts upstream of or within several processes, including gene expression; negative regulation of gene expression; and regulation of phosphate transport. Located in cell surface and perinuclear region of cytoplasm. Is expressed in several structures, including genitourinary system; intestine; lung; stomach; and trunk. Orthologous to human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase).
PHENOTYPE: Homozygotes for targeted null mutations exhibit male infertility due to impaired sperm maturation in the epididymis. Mutant sperm are capable of fertilization in vitro but not in vivo. [provided by MGI curators]
  • synonyms:
  • c-ros,
  • MGD-MRK-14011,
  • Ros1 proto-oncogene,
  • MGD-MRK-14010,
  • Ros-1,
  • Ros1

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For