| First Author | Stewart C | Year | 1983 |
| Journal | Science | Volume | 221 |
| Issue | 4612 | Pages | 760-2 |
| PubMed ID | 6683871 | Mgi Jnum | J:7153 |
| Mgi Id | MGI:55624 | Doi | 10.1126/science.6683871 |
| Citation | Stewart C, et al. (1983) X chromosome-linked transmission and expression of retroviral genomes microinjected into mouse zygotes. Science 221(4612):760-2 |
| abstractText | A genomic clone consisting of the Moloney leukemia proviral genome with moderately repetitive mouse sequences was microinjected into the pronucleus of a mouse zygote. An animal was derived that carried multiple copies of proviral DNA in a tandem array. No evidence for homologous recombination was obtained. The viral genome was expressed in this animal and was transmitted as a single unit to its offspring. Subsequent breeding studies revealed that the proviral DNA had integrated on an X chromosome. |
