| First Author | Rodríguez-Alba JC | Year | 2018 |
| Journal | Eur J Immunol | Volume | 48 |
| Issue | 11 | Pages | 1851-1860 |
| PubMed ID | 30289564 | Mgi Jnum | J:267205 |
| Mgi Id | MGI:6256596 | Doi | 10.1002/eji.201847547 |
| Citation | Rodriguez-Alba JC, et al. (2018) Regulatory IFN-gamma-producing killer dendritic cells are enhanced in B6.MLR-Fas(lpr) /J lupus-prone mice. Eur J Immunol 48(11):1851-1860 |
| abstractText | A novel cell population denominated IFN-gamma-producing killer dendritic cells (IKDCs) have been recently described. These cells are lymphocytes lacking B- or T- receptors, but they can be identified by the presence of B220(+) CD38(+) CD49b(+) and low CD11c, among other cell surface markers. The main characteristics of IKDCs are the production of IFN-gamma and the ability to spontaneously kill tumor cells. We found that this population increases in B6.MLR-Fas(lpr) /J mice. Interestingly, IKDCs increase with age and are more abundant in mice older than 6 months onward. To analyze whether these cells have any role in the induction of the lupus-like phenotype in the B6.MLR-Fas(lpr) /J mice, IKDCs were purified and transferred into 6-month-old B6.MRL-Fas(lpr) /J mice, then the presence of anti-nuclear antibodies (ANAS) and anti-dsDNA antibodies were analyzed 2 and 4 months after the transfer. The results showed a reduction in the levels of these autoantibodies and increased survival of these mice, indicating that these cells may have a regulatory function. In vitro assays demonstrated that IKDCs reduced the proliferation of both autoreactive B and T cells, suggesting that these may be the mechanisms used by these cells to ameliorate the lupus-like phenotype in the B6.MRL-Fas(lpr) /J mice. |
