| First Author | Persons DA | Year | 1999 |
| Journal | Nat Genet | Volume | 23 |
| Issue | 2 | Pages | 159-65 |
| PubMed ID | 10508511 | Mgi Jnum | J:57881 |
| Mgi Id | MGI:1345910 | Doi | 10.1038/13787 |
| Citation | Persons DA, et al. (1999) Fv2 encodes a truncated form of the Stk receptor tyrosine kinase [see comments]. Nat Genet 23(2):159-65 |
| abstractText | The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2ss) erythroid cells, was not expressed in Fv2 resistant (Fv2rr) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia. |
