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Publication : Early lethality of beta-1,4-galactosyltransferase V-mutant mice by growth retardation.

First Author  Kumagai T Year  2009
Journal  Biochem Biophys Res Commun Volume  379
Issue  2 Pages  456-9
PubMed ID  19114028 Mgi Jnum  J:144516
Mgi Id  MGI:3831059 Doi  10.1016/j.bbrc.2008.12.078
Citation  Kumagai T, et al. (2009) Early lethality of beta-1,4-galactosyltransferase V-mutant mice by growth retardation. Biochem Biophys Res Commun 379(2):456-9
abstractText  The beta-1,4-galactosyltransferase (beta-1,4-GalT) V whose human and mouse genes were cloned by us has been suggested to be involved in the biosynthesis of N-glycans and O-glycans, and lactosylceramide. To determine its biological function, beta-1,4-GalT V (B4galt5) mutant mice obtained by a gene trap method were analyzed. Analysis of pre- and post-implantation embryos revealed that the B4galt5(-/-) mice die by E10.5 while B4galt5(+/-) mice were born and grown normally. Histological study showed that most tissues are formed in B4galt5(-/-) embryos but their appearance at E10.5 is close to that of B4galt5(+/-) embryos at E9.0-9.5. The results indicate that the growth is delayed by one to one and half day in B4galt5(-/-) embryos when compared to B4galt5(+/-) embryos, which results in early death of the embryos by E10.5, probably due to hematopoietic and/or placental defects.
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