| First Author | Hashimoto T | Year | 2005 |
| Journal | Biosci Biotechnol Biochem | Volume | 69 |
| Issue | 1 | Pages | 209-11 |
| PubMed ID | 15665488 | Mgi Jnum | J:96275 |
| Mgi Id | MGI:3529891 | Doi | 10.1271/bbb.69.209 |
| Citation | Hashimoto T, et al. (2005) Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice. Biosci Biotechnol Biochem 69(1):209-11 |
| abstractText | Y-700, 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid, is a newly synthesized inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-dimethylhydrazine-treated mice, accompanied by reduced serum urate. These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer. |
