| First Author | Wang CY | Year | 1996 |
| Journal | Science | Volume | 274 |
| Issue | 5288 | Pages | 784-7 |
| PubMed ID | 8864119 | Mgi Jnum | J:36491 |
| Mgi Id | MGI:83918 | Doi | 10.1126/science.274.5288.784 |
| Citation | Wang CY, et al. (1996) TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB [see comments]. Science 274(5288):784-7 |
| abstractText | Many cells are resistant to stimuli that can induce apoptosis, but the mechanisms involved are not fully understood. The activation of the transcription factor nuclear factor-kappa B (NF-kappaB) by tumor necrosis factor (TNF), ionizing radiation, or daunorubicin (a cancer chemotherapeutic compound), was found to protect from cell killing. Inhibition of NF-kappaB nuclear translocation enhanced apoptotic killing by these reagents but not by apoptotic stimuli that do not activate NF-kappaB. These results provide a mechanism of cellular resistance to killing by some apoptotic reagents, offer insight into a new role for NF-kappaB, and have potential for improvement of the efficacy of cancer therapies. |
