| Primary Identifier | MGI:97440 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 18389 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables nociceptin receptor activity. Involved in neuron-neuron synaptic transmission and sensory perception of pain. Acts upstream of or within G protein-coupled opioid receptor signaling pathway. Is active in synaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and peripheral nervous system ganglion. Orthologous to human OPRL1 (opioid related nociceptin receptor 1). PHENOTYPE: Mice homozygous for a null allele exhibit altered touch/nociception, facilitation of long-term potentiation and memory, increased dopamine release upon administration of opioid peptide agonist, impaired behavioral response to morphine, and increased susceptibility to noise-induced hearing loss. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
