| First Author | Li S | Year | 2007 |
| Journal | Blood | Volume | 110 |
| Issue | 12 | Pages | 3926-35 |
| PubMed ID | 17630353 | Mgi Jnum | J:149130 |
| Mgi Id | MGI:3847638 | Doi | 10.1182/blood-2007-01-065482 |
| Citation | Li S, et al. (2007) Rapidly induced, T-cell independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells. Blood 110(12):3926-35 |
| abstractText | Xenoantibody production directed at a wide variety of T lymphocyte-dependent and T lymphocyte-independent xenoantigens remains the major immunologic obstacle for successful xenotransplantation. The B lymphocyte subpopulations and their helper factors, involved in T-cell-independent xenoantibody production are only partially understood, and their identification will contribute to the clinical applicability of xenotransplantation. Here we show, using models involving T-cell-deficient athymic recipient mice, that rapidly induced, T-cell-independent xenoantibody production is mediated by marginal zone B lymphocytes and requires help from natural killer (NK) cells. This collaboration neither required NK-cell-mediated IFN-gamma production, nor NK-cell-mediated cytolytic killing of xenogeneic target cells. The T-cell-independent IgM xenoantibody response could be partially suppressed by CD40L blockade. |
