Primary Identifier | IPR043268 | Type | Family |
Short Name | UNC93B1 |
description | UNC93B1 is a multi-transmembrane domain-containing protein that plays an essential role in signalling by the nucleotide-sensing Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9 [, ]. UNC93B1 delivers the nucleotide-sensing receptors TLR7 and TLR9 from the ER to endolysosomes []. It has been shown to recruit Syntenin-1 and dampen TLR7 signalling and prevent autoimmunity []. It also binds TLR9, and the release of TLR9 from UNC93B1 is required for TLR9 to function []. Mutations in the UNC93B1 gene that result in aberrant TLR trafficking can lead to autoimmune disease []. |