| First Author | de Heusch M | Year | 2004 |
| Journal | Immunol Lett | Volume | 94 |
| Issue | 3 | Pages | 229-37 |
| PubMed ID | 15275971 | Mgi Jnum | J:110989 |
| Mgi Id | MGI:3652482 | Doi | 10.1016/j.imlet.2004.05.009 |
| Citation | de Heusch M, et al. (2004) The heat stable antigen (CD24) is not required for the generation of CD4+ effector and memory T cells by dendritic cells in vivo. Immunol Lett 94(3):229-37 |
| abstractText | Previous work has established that CD24 is a costimulatory molecule for T-cell clonal expansion. Studies using CD24 -/- mice demonstrated that CD24 plays a critical role in the CD28-independent immune response against virus and soluble antigens. The role of CD24 on dendritic cells (DCs) has not been reported. Here, we compare the CD24(+/+) and CD24(-/-) DCs in the induction of initial clonal expansion and elicitation of memory CD4(+) T cells in vivo. Our results demonstrate that the CD24 expressed on DCs is essential neither for the induction of initial T-cell clonal expansion nor for elicitation of memory activity of primed T cells in vivo. |
