| Primary Identifier | IPR029364 | Type | Family |
| Short Name | ALKL1/2 |
| description | This entry includes ALK and LTK ligand 1 and 2 (ALKL1/2, also known as FAM150A and FAM150B, respectively) from vertebrates. ALKL1/2 are activating ligands for the receptor anaplastic lymphoma kinase (ALK) and the receptor leukocyte tyrosine kinase (LTK) [, ]. However, ALKL1 does not act as a potent physiological ligand for ALK, in contrast to ALKL2 [, ]. Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation [, ]. It is not yet clear if ALKL2 activates ALK as a homodimer or a monomer [, ]. |
