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Protein Coding Gene : Psme2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Primary Identifier  MGI:1096365 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  19188
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Contributes to endopeptidase activator activity. Acts upstream of or within antigen processing and presentation of exogenous antigen. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including heart; hemolymphoid system; liver; lung; and pancreas. Orthologous to human PSME2 (proteasome activator subunit 2).
PHENOTYPE: Homozygous disruption of this gene results in impaired cytotoxic T lymphocyte responses and immunoproteasome assembly. [provided by MGI curators]
  • synonyms:
  • expressed sequence AI788882,
  • MGI:2144028,
  • PA28b,
  • AA589371,
  • AI788882,
  • proteasome (prosome, macropain) activator subunit 2 (PA28 beta),
  • Psme2,
  • expressed sequence AA589371,
  • MGI:2145690
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Genome

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1 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

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Homology

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122 Pathways

Trail: ProteinCodingGene

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Expression

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Phenotype

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