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Allele : Camsap3<tm1.1Ltm> calmodulin regulated spectrin-associated protein family, member 3; targeted mutation 1.1, Masatoshi Takeichi
Primary Identifier  MGI:5912533 Allele Type  Targeted
Gene  Camsap3 Transmission  Germline
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  A loxP site and FRT-flanked neo cassette were inserted in intron 13 and a loxP site was inserted in intron 17 via homologous recombination. Cre-mediated recombination removed the neo cassette and exons 14-17. RT-PCR confirmed the expression of a truncated transcript lacking the CKK domain essential for the binding to microtubules. In polarized epithelial cells the mutant protien fails to collect in the apical cortical area of cell-cell junctions.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • Camsap3<dc>,
  • Camsap3<dc>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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6 Publication categories

Trail: Allele




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