| First Author | Veillette A | Year | 1988 |
| Journal | Cell | Volume | 55 |
| Issue | 2 | Pages | 301-8 |
| PubMed ID | 3262426 | Mgi Jnum | J:225417 |
| Mgi Id | MGI:5693239 | Doi | 10.1016/0092-8674(88)90053-0 |
| Citation | Veillette A, et al. (1988) The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 55(2):301-8 |
| abstractText | The CD4 and CD8 T cell antigens are thought to transduce an independent signal during the process of T cell activation. We report our evaluation of the possible involvement of the lymphocyte-specific tyrosine kinase p56lck in these transduction pathways. Our data demonstrate that p56lck is specifically modulated with either CD4 or CD8 following antibody-mediated cross-linking of these molecules and that a large fraction of the total cellular lck protein can be coimmunoprecipitated with these surface glycoproteins. These results suggest that p56lck is functionally and physically associated with CD4/CD8 in normal murine T lymphocytes and support the concept that an independent signal is transduced by the interaction of these surface molecules with major histocompatibility complex determinants. |
