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Publication : Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.

First Author  Wang D Year  2012
Journal  Nat Immunol Volume  13
Issue  6 Pages  560-8
PubMed ID  22561606 Mgi Jnum  J:186446
Mgi Id  MGI:5432321 Doi  10.1038/ni.2301
Citation  Wang D, et al. (2012) Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol 13(6):560-8
abstractText  Signaling via the T cell antigen receptor (TCR) during the CD4(+)CD8(+) double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell-expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1(-/-) mice had fewer mature thymic CD4(+) and CD8(+) T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-gamma1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk-AP-1 and Ca(2+)-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.
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