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Comment :

Type  MGI:General Description  plasma and brain levels and urinary excretion of M3G (metabolite of morphine) are significantly lower 30 minutes after morphine injection compared to wild-type mice hepatic and biliary levels of M3G are increased and excretion pathway of morphine and M3G is shifted from the urinary to gastrointestinal after injection of M3G, plasma levels of M3G are lower and detectable levels are morphine are seen in the plasma unlike in wild-type mice